Certain diabetes drugs must warn of deadly flesh-eating genital infection, FDA says

Modal Trigger Getty Images  iStock

Modal Trigger Getty Images iStock

THURSDAY, Aug. 30, 2018 (HealthDay News) - Rare but serious genital infections, as well as one death, have been reported in some patients taking a certain class of type 2 diabetes medicine, the U.S. Food and Drug Administration says. From the FDA's release which occurred this Wednesday, we can see more than a dozen drugs listed which will have to warn of the infection from now on.

The FDA's warning is for a class of medicines called SGLT2 inhibitors used by adults with Type 2 diabetes to lower blood sugar.

Patients are at risk of the infection known as Fournier's gangrene, an extremely rare but life-threatening bacterial infection of the tissue under the skin that surrounds the genital area, the FDA said in a statement, adding that more cases may be uncovered once the risk is better understood.

The FDA said it identified 12 cases of Fournier's gangrene - 7 in men and 5 in women - between March 2013 and May 2018.

Invokana, Invokamet XR, Steglatro, Farxiga, Synjardy, Synjardy XR, Xigduo XR, Qtern, Invokamet, Jardiance, Glyxambi, Segluromet and Steglujan are brand names of SGLT2 inhibitors green-lighted by health regulators.

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The 12 cases include only those reported and those in medical literature, which means that there are possibly more unidentified cases. If Fournier's gangrene is suspected, originate medication all of a sudden with mountainous-spectrum antibiotics and surgical treatment if significant, pause the SGLT2 inhibitor, closely visual show unit blood sugar ranges, and provide acceptable different therapy for blood sugar serve an eye fixed on, the agency added.

All were hospitalized and needed surgery, the FDA said. One patient died, the FDA reported.

The infection has been identified in seven men and five women in the U.S. in the last five years, but the FDA warned that more patients have been affected.

Healthcare professionals should assess patients for Fournier's gangrene if they present with tenderness, redness or swelling of the genitals or the area from the genitals back to the rectum and have a fever above 100.4 F or a general feeling of being unwell, the FDA said.

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