Boris Johnson's brother resigns and calls for a second Brexit referendum

Theresa May leaves the back of Number 10 Downing Street

Theresa May leaves the back of Number 10 Downing Street

The Prime Minister endured a tough weekend following the resignation of transport minister Jo Johnson over the government's handling of Brexit negotiations, which are reported to be on the brink of falling apart following the EU's rejection of one of May's key solutions to avoiding a hard border in Northern Ireland.

In a video on Twitter, Johnson said the United Kingdom was "barrelling" towards an incoherent Brexit, leaving the nation "trapped" in an subordinate relationship to the European Union.

It was "imperative" to "go back to the people and check they are content to proceed on this extraordinary basis". "Now is the time for people to stand up for what they believe in or we will sleepwalk to a #Brexit disaster".

To add to the pressure, a leading member of a group of Brexiteer lawmakers in parliament joined with the Brexit spokesman for the small Northern Irish party that props up May's party in government to warn that they could not vote for the deal as it now stands. "To present the nation with a choice between two deeply unattractive outcomes, vassalage and chaos, is a failure of British statecraft on a scale unseen since the Suez crisis".

A Downing Street spokesman said: 'The referendum in 2016 was the biggest democratic exercise in this country's history.

People's Vote campaigners think the most realistic route to another referendum is that parliament votes down May's deal and the opposition Labour Party fails to trigger a general election.

But the alternative will be equally damaging, he said.

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A senior cabinet minister was quoted in the paper as saying: "This is the moment she has to face down Brussels and make it clear to them that they need to compromise, or we will leave without a deal".

The deal being negotiated with Europe by the government - dubbed the "Chequers Deal" - would leave Britain economically weakened with no say in European Union rules it would have to adhere to for years, while a "no deal" scenario would inflict damage on the country.

With the shock resignation of pro-European Jo Johnson continuing to cause ructions in Tory ranks, and speculation that four more ministers could be set to follow his example, Mrs May is running out of time to seal an European Union exit agreement.

"Theresa May is in office, but not in power".

"And you can be absolutely sure that this idea will be at the heart of the "deal" that I have no doubt the prime minister will shortly and magically secure".

"He has not done that".

"The destination is constitutional crisis, where legislature will be in irreconcilable conflict with executive, Commons at odds with PM and her cabinet", Peston said in a post on Facebook.

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