Second patient ever in HIV remission after stem cell transplant

A HIV positive man known as the London Patient has become the second known person to show long term remission from HIV

A HIV positive man known as the London Patient has become the second known person to show long term remission from HIV

The first, Timothy Ray Brown, known as the "Berlin Patient", was reported 12 years ago. Specifically, the donor had two copies of a version of the CCR5 gene.

"We haven't cured HIV, but [this] gives us hope that it's going to be feasible one day to eliminate the virus", she said.

"By achieving remission in a second patient using a similar approach, we have shown that the Berlin patient was not an anomaly", said lead author Ravindra Gupta, a professor at the University of Cambridge, referring to the first known functional cure. CCR5 is known to be a co-receptor for HIV, so mutations in it can help people to become resistant to infection.

One such effort is the IAS Towards an HIV Cure initiative established in 2012 to promote and facilitate the search for a safe and affordable cure that can be scaled up.

The study will also be presented at an HIV conference in Seattle. Even if the CCR5 mutation wasn't extremely rare, you'd still have to match the immunological footprints of the donor and the patient to prevent the bone marrow from reacting badly to the recipient. The patient remained on anti-HIV drugs to prevent the virus from replicating for almost 1.5 years after the transplant; because HIV tends to hide in cells in a dormant phase and reactivate years later, Gupta wanted to be sure that as much of the virus as possible was destroyed with the drugs.

A second person has gone into remission from HIV after receiving a stem cell transplant, doctors have announced.

Both the first patient to be cured of H.I.V., Timothy Ray Brown, who is now 52 and was cured in 2007, and the new patient, whom scientists refer to as the "London patient", were afflicted with forms of cancer and were given bone-marrow transplants meant to treat their cancers, not the H.I.V virus, according to The New York Times.

Gupta, now at Cambridge University, treated the London patient when he was working at University College London.

Moon calls for swift resumption of U.S.-North Korea talks
Pentagon officials say instead of the massive war games, the US and South Korea will hold a series of small-scale exercises. National security adviser John Bolton listens during a press briefing at the White House, Jan. 28, 2019, in Washington .

The study stated: "Firstly, the bone marrow transplant in both HIV cure cases were primarily used to treat cancers of the blood and were modified to enable a HIV cure". "Some of them are directly related to the Berlin patient and work with transplantation: for example, gene modification therapy".

Using bone marrow transplants to cure HIV in everyone who has the virus, though, remains impractical, expensive, and risky.

Gero Hütter, the German hematologist who treated Timothy Ray Brown, said: "By repeating the procedure in another patient, there is more evidence that the "Berlin patient" is not a sole exception".

Millions of people infected with HIV around the world keep the disease in check with so-called antiretroviral therapy (ARV), but the treatment does not rid patients of the virus.

Specialists said it was not yet clear whether the CCR5 resistance is the only key - or whether the graft-versus-host disease may have been just as important.

But a reservoir of cells carrying HIV can still remain in the body, in a resting state, for many years.

Brown, though, had undergone more severe treatment than the London patient and for a while researchers believed that his near-death experience was key to curing HIV.

Recommended News

  • Where the investigations related to President Trump stand

    Where the investigations related to President Trump stand

    However, the Washington Post documented that Trump made 8,158 false or misleading claims in his first two years in office. The committee interviewed Cohen in private on Thursday and will finish the interview this coming Wednesday.

    WWE Star King Kong Bundy Dead At Age 61

    To further push dominance, he would demand referees count to five instead of the normal three. WWE has officially released a statement regarding the passing of WWE legend King Kong Bundy .
    Macron unveils plan for 'European renaissance' ahead of key EU vote

    Macron unveils plan for 'European renaissance' ahead of key EU vote

    Macron suggested Europe should also share a common border force, along with a joint office for dealing with asylum demands. The establishment of the European Council for Internal Security .
  • This former National Football League  and Miami Hurricanes star lands back in jail

    This former National Football League and Miami Hurricanes star lands back in jail

    He has pleaded not guilty to multiple counts of kidnapping, rape and other charges related to those accusations. Winslow, a 2007 Pro Bowler with Cleveland, last played in the National Football League in 2013 with the Jets.
    Low axes Bayern trio from Germany squad

    Low axes Bayern trio from Germany squad

    Germany captain Manuel Neuer , 32, has a battle to keep his goalkeeping shirt from Barcelona's Marc-Andre ter Stegen, 26. I'm convinced that that is the correct step. "They are big players who stand for a big time in the national team".
    Trump's new attorney general William Barr won't recuse himself in Mueller probe

    Trump's new attorney general William Barr won't recuse himself in Mueller probe

    During his hearing, Barr referred to the report as "confidential", but said the attorney general could release a separate report on Mueller's findings.
  • Arrests Made During Sacramento Police Shooting Protests

    Arrests Made During Sacramento Police Shooting Protests

    At a demonstration Monday night, police arrested dozens of people, including several clergy members and local journalists . They were pursuing him after receiving calls about someone breaking vehicle windows and a neighbor's sliding glass door.
    WWE legend King Kong Bundy dead at age 61

    WWE legend King Kong Bundy dead at age 61

    Later in his career, King got one more run in WWE highlighted by a coveted match against The Undertaker at WrestleMania XI . Gregory Helms, also known as Hurricane Helms in WWE , posted a picture of him shaking hands with Bundy.
    Failure to replace Ronaldo's goals is Real's 'biggest problem' - Modric

    Failure to replace Ronaldo's goals is Real's 'biggest problem' - Modric

    Ronaldo quit Real for Juventus last summer where he is now setting new goalscoring records. But we don't have that. "That's why I think scoring is our biggest problem this season".
  • Tiger Woods withdraws from Arnold Palmer Invitational with neck strain

    Tiger Woods withdraws from Arnold Palmer Invitational with neck strain

    Instead of rest, and in a somewhat surprising decision, Woods travelled directly to Mexico to play in the WGC Mexico Championship. He did make sure to note that his injury is not considered long-term.
    Fortnite's Next Battle Pass Will Be Conditionally Free

    Fortnite's Next Battle Pass Will Be Conditionally Free

    Not only have we got Overtime challenges to be grinding out, there's also a free Fortnite Season 8 Battle Pass up for grabs. All you need to do is head to that place right in between Lonely Lodge and Retail Row to reach the Fortnite RV Park .
    French tax on net giants could yield 500m euros a year

    French tax on net giants could yield 500m euros a year

    A 3% French tax would be levied on mostly US internet companies earning global digital revenue of at least 750 million euros. But companies such as Amazon earning money as a digital intermediary between a producer and a client would have to pay.

We are pleased to provide this opportunity to share information, experiences and observations about what's in the news.
Some of the comments may be reprinted elsewhere in the site or in the newspaper.
Thank you for taking the time to offer your thoughts.