CDC panel recommends HPV vaccine for men up to age 26

HPV Vaccine Is Having a “Substantial Impact,” May Decrease Rate of Cervical Cancer

HPV Vaccine Is Having a “Substantial Impact,” May Decrease Rate of Cervical Cancer

The Advisory Committee on Immunization Practices' vote in Atlanta raises the recommended vaccination age for men from 21 to 26, making it the same as the existing recommendation for women. The earlier recommendation for teen boys and young men went through age 21.

Instead, it settled on a weak endorsement for adults between 26 and age 45, meaning patients and doctors can make the decision together.

The CDC's earlier HPV recommendations haven't changed. But the CDC routinely adopts ACIP's recommendations.

Researchers who reviewed 65 studies in 14 high-income countries found that since the vaccine was introduced in 2006, there has been a "substantial" decrease in HPV infections and related conditions.

"These results provide strong evidence of HPV vaccination working to prevent cervical cancer in real-world settings, as HPV infections - which are the cause of cervical cancer - and precancerous cervical lesions are significantly declining", said Prof.

Anogenital wart diagnoses decreased significantly by 67% (RR=0.33; 95% CI, 0.24-0.46) among girls aged 15 to 19 years, by 54% (RR=0.46; 95% CI, 0.36-0.60) among women aged 20 to 24 years, and by 31% (RR=0.69; 95% CI, 0.53-0.89) among women aged 25 to 29 years.

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Countries with multi-cohort vaccination and high HPV vaccine coverage saw greater and faster impacts, along with herd effects.

The vaccine is approved for people up to age 45, but the same panel declined a proposal to recommend it for people older than 26.

HPV vaccines were first licensed in 2007 and have since then been adopted in at least 100 countries worldwide. Analyses were stratified by sex, age, and years since the introduction of the HPV vaccination.

"Because of our finding, we believe the World Health Organization call for action to eliminate cervical cancer may be possible in many countries if sufficient vaccination coverage can be achieved", study author Marc Brisson, PhD, a professor at Laval University in Quebec, Canada, told CNBC.

"The authors emphasize the importance of redoubling our efforts to tackle the fiscal, supply, and programmatic barriers that now limit HPV vaccine programmes", Sanjose and Delany-Moretlwe wrote.

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