Studies Detail Syndrome in Kids Linked to COVID

Provided by NBC New York Doctors are investigation a rare but serious syndrome linked to COVID-19

Provided by NBC New York Doctors are investigation a rare but serious syndrome linked to COVID-19

Almost 100 of the cases detailed in the studies came from NY state, which has been the epicenter of the coronavirus pandemic in the U.S. However, in early May, this hyperinflammatory process in children occurred in the United Kingdom, several other European countries, and across the U.S. "Still, with proper identification and treatment, thankfully the majority of these children and adolescents get better and many do so very quickly".

According to Levin, the first study was led by Boston Children's Hospital, found 186 cases of MIS-C in the U.S. The study stated that four out of five who had the symptoms and were in need of mechanical ventilation had died.

The other study, separate from the one at Children's, looked at data from NY state involving 95 patients with confirmed MIS-C. In both studies, numerous children developed cardiovascular and clotting problems and many had gastrointestinal symptoms. Socioeconomic and environmental factors also need to be considered for the high prevalence amongst certain demographics. However, Randolph said numerous children in the study did not meet all criteria for that diagnosis.

Many young COVID-19 patients in Mumbai have shown symptoms similar to Kawasaki disease. "Fever, rash and I think especially in the setting of areas where you have a lot of coronavirus infections, SARS-CoV-2 infections - have a lower threshold for seeking care, I would say". They used six criteria as their case definition - serious illness requiring hospitalization, 21 years or younger, fever for at least 24 hours, laboratory evidence of inflammation, multisystem organ involvement, and laboratory confirmed SARS-CoV-2 infection.

Of the 27 children with Covid-19 Paediatric Inflammatory Multisystem Syndrome, four who were previously healthy had new-onset neurological symptoms.

It is not clear why MIS-C develops in some children and adolescents and not in others. Few of the children are under the age of 5.

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As a further result of their studies, the scientists pointed out that MIS-C occurs only very rarely: Two out of 100,000 people under the age of 21 suffered accordingly of it.

The researchers then expanded the study to include many more cases from the original hotspots in the NY and New Jersey region.

"Among our patients, predominantly from the New York Metropolitan Region, 40% were Black and 36% were Hispanic".

The study authors added that the incidence of MIS-C "coincided with widespread SARS-CoV-2 transmission; this hyperinflammatory syndrome with dermatologic, mucocutaneous, and gastrointestinal manifestations was associated with cardiac dysfunction".

The average age of the patients with MIS-C was 8 years.

The U.K. definition of "pediatric inflammatory multisystem syndrome temporally associated with SARS-CoV-2" (PIMS) released in April was followed by a narrower definition released in May by the CDC and World Health Organization for MIS-C.

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