Patients suffer fatigue after recovering from Covid 19

Half of Covid patients in Irish study suffer ongoing fatigue

Half of Covid patients in Irish study suffer ongoing fatigue

The news is a boost for Roche after Actemra, a retooled rheumatoid arthritis medicine that fights inflammation, failed a separate late-stage clinical trial earlier this year in patients hospitalised with severe COVID-19 related pneumonia.

"This is particularly relevant given the limitations of now available Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) reverse transcriptase-polymerase chain reaction (RT-PCR) testing as it takes time to complete the test and sometimes it is inaccurate", said study author Tom Booth. In addition, the researchers also took into account the severity of the patient's initial infection - if they required hospitalization, for instance - as well as any other pre-existing conditions they had that could contribute to the fatigue, such as depression.

The research team used a commonly-used scale to determine fatigue in recovered patients for the study, called the Chalder Fatigue Score (CFQ-11).

They also looked at various markers of immune activation (white cell counts, C-reactive protein, Interluekin-6, and sCD25).

The researchers "investigated whether patients recovering from SARS-CoV-2 infection remained tired after their physical recovery, and to see whether there was a relationship between severe fatigue and a variety of clinical parameters", said Townsend.

More than half reported persistent fatigue (52.3 per cent; 67/128) at this point.

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Roche ROG.S shares closed higher on Friday after the Swiss drugmaker said a study had shown its drug Actemra helped against COVID-19 and announced the release of a new antibody test as well as a European recommendation for a liver cancer cocktail.

Patients with COVID-19 associated pneumonia, who received Actemra plus standard of care, were 44 percent less likely to progress to mechanical ventilation, or death, compared to patients who received placebo plus standard of care.

"Fatigue was found to occur independent of admission to hospital, affecting both groups equally", said Townsend.

Officials also noted that the trial was the first to primarily use patients who are often "underrepresented in clinical studies and have been disproportionately affected by the COVID-19 pandemic".

"Our findings demonstrated a significant burden of post-viral fatigue in individuals with previous SARS-CoV-2 infection after the acute phase of Covid-19 illness", the study authors wrote. We do not accept any responsibility or liability for the accuracy, content, images, videos, licenses, completeness, legality, or reliability of the information contained in this article.

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