Late-stage trial data shows COVID-19 vaccine is over 90% effective

Watershed Covid-19 vaccine proves 90 percent effective

Watershed Covid-19 vaccine proves 90 percent effective

The companies that announced their mRNA-based vaccine candidate, BNT162b2, against SARS-CoV-2 has demonstrated evidence of efficacy against COVID-19 in a Phase III clinical study.

The companies hope that the addition of these new secondary endpoints will help to "align data" across all COVID-19 vaccine studies, by enabling for cross-trial learnings and comparisons between novel vaccine platforms.

The initial analysis looked at first 94 confirmed cases among over 43,000 volunteers who either received two doses of the vaccine or placebo.

Prof Ghani said: "These new results represent the first demonstration of substantial efficacy of a vaccine candidate against Covid-19 disease, which is very welcome news".

"We are reaching this critical milestone in our vaccine development programme at a time when the world needs it most, with infection rates setting new records, hospitals nearing over-capacity and economies struggling to reopen", said Albert Bourla, chairman and chief executive officer of Pfizer.

But others pointed out that there would likely be significant logistical problems in getting the vaccine to everyone, especially given it must be kept super-cooled and now requires two doses to bestow immunity. What are the caveats?

The company says it is on track to submit a request for Emergency Use Authorization (EUA) in the United States after the required safety milestone in the third week of November.

Nvidia announces RTX 3060 Ti with ray tracing and DLSS for $399
The RTX 3060 can be seen as a replacement for the RTX 2060 Super, but in terms of specs, it is a toned version of the RTX 3070 . Like all of Nvidia's other RTX 3000 cards, the 3060 Ti supports real-time ray tracing and DLSS support.

To date, the independent Data Monitoring Committee has not reported any serious concerns or side effects and data collected will be discussed with regulatory authorities around the world.

"The efficacy estimate is based on seven days of follow-up of participants following the second dose; further data in the coming weeks and months will provide a better picture of longer-term vaccine efficacy". Since this is the amount of safety data specified by the US FDA in its guidance for potential Emergency Use Authorisation, it is likely that the firms will be able to approach the regulator for emergency approval then.

Pfizer and German partner BioNTech SE are the first drugmakers to show successful data from a large-scale clinical trial of a coronavirus vaccine.

The vaccine has been shown to produce both an antibody and T-cell response in the body to fight coronavirus.

John Bell, an Oxford University professor and vaccines adviser to the United Kingdom government, welcomed the news and went as far as to say life could begin to return to normal by spring.

India is focussed on five other Covid-19 vaccine candidates being tested by Serum Institute of India, Bharat Biotech, Zydus Cadila, Dr Reddy's Laboratories and Biological E.

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