How will SARS-CoV-2 severity change in the next decade?

Coronavirus symptoms could be akin to common cold in the future study suggests

Coronavirus symptoms could be akin to common cold in the future study suggests

"Improving the geographic coverage of sequencing is critical for the world to have eyes and ears on changes to the virus", said Dr Maria Van Kerkhove, Technical Lead on COVID-19, WHO.

The Consortium will bring together leading virologists from ten research institutions including the University of Bristol. The results suggest mosaic nanoparticles as a candidate vaccine to protect against COVID-19 and other emerging coronaviruses with human spillover potential, write Cohen and team.

"This is critical research which will feed into government decision-making on a daily basis".

As new virus variants arise, the consortium will flag the riskiest variants, such as those associated with fast spreading virus clusters, to study.

The other two viruses studied, SARS and MERS, are more deadly, but did not circulate as widely. This is important because changes to the spike protein can affect transmissibility and could potentially alter the effectiveness of vaccines and antibodies that target the protein.

Susceptibility to infection and ability to infect others is also infected by other factors, including whether SARS-CoV-2 can replicate once inside cells and the animal's ability to fight off the virus.

This knowledge could be key to future research identifying viruses circulating in animals that could adapt to infect humans - known as zoonoses - and which could pose a pandemic threat. It is recommended that such individuals wait at least a month for their immune response to the vaccine to be better than it would be if the vaccine was administered earlier than that.

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"Frankly, I don't know, and frankly, I'm staying out of this". "I literally don't know". Pfizer declined an invitation to the event, the spokesperson confirmed.

"We already knew that our immune response was not mounting a successful defense to COVID-19, but we didn't know why", said lead author Brendan Miller, a senior doctoral student at the USC Leonard Davis School, in the press release. Their analysis of the immunological and epidemiological data for these viruses helped them develop a model to predict the trajectory of SARS-CoV-2 as it becomes endemic. This may have played an important role in allowing the virus to jump the species barrier.

There are two new variants in Brazil, the more concerning of which has been picked up in travellers going to Japan but has not been detected in the United Kingdom, while the other has.

The researchers say that SARS-CoV-2 enters lung cells by binding to a protein called angiotensin-converting enzyme 2 (ACE2) and the team determined that the ACE2 protein is produced by neurons and that blocking this protein prevents the virus from human brain organoids.

They found SARS-CoV-2 spikes containing RaTG13 regions were unable to bind to human ACE2 receptors effectively.

Professor Wendy Barclay, head of the Department of Infectious Disease, will lead the United Kingdom team, which brings together leading virologists from 10 research institutions, including King's College London, University of Glasgow and the Pirbright Institute. The latest peer-reviewed study, published last week in Science, echoes several non-peer-reviewed studies published a year ago.

This article is based on materials from UK Research & Innovation. It is composed of seven disciplinary research councils, Innovate UK and Research England.

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